منابع مشابه
Mechanical force generation by G proteins.
GTP-hydrolyzing G proteins are molecular switches that play a critical role in cell signaling processes. Here we use molecular dynamics simulations to show that Ras, a monomeric G protein, can generate mechanical force upon hydrolysis. The generated force levels are comparable to those produced by ATP-hydrolyzing motor proteins, consistent with the structural similarities of the catalytic regio...
متن کاملForce generation by kinesin and myosin cytoskeletal motor proteins.
Kinesins and myosins hydrolyze ATP, producing force that drives spindle assembly, vesicle transport and muscle contraction. How do motors do this? Here we discuss mechanisms of motor force transduction, based on their mechanochemical cycles and conformational changes observed in crystal structures. Distortion or twisting of the central β-sheet - proposed to trigger actin-induced Pi and ADP rele...
متن کاملForce Generation by Cellular Polymers
1. Actin and tubulin polymerization and depolymerization can generate mechanical forces using the free energy of monomer binding and/or nucleotide hydrolysis as their energy source. 2. Polymers can also store elastic energy during their polymerization that can be released later to generate mechanical forces that drive some of the most rapid of cellular motions. 3. Actin and tubulin are tracks f...
متن کاملMasked cyanoacrylates unveiled by mechanical force.
Mechanical damage of polymers is often a destructive and irreversible process. However, desirable outcomes may be achieved by controlling the location of chain cleavage events through careful design and incorporation of mechanically active chemical moieties known as mechanophores. It is possible that mechanophores can be used to generate reactive intermediates that can autopolymerize or cross-l...
متن کاملProbing complex RNA structures by mechanical force.
RNA secondary structures of increasing complexity are probed combining single molecule stretching experiments and stochastic unfolding/refolding simulations. We find that force-induced unfolding pathways cannot usually be interpreted by solely invoking successive openings of native helices. Indeed, typical force-extension responses of complex RNA molecules are largely shaped by stretching-induc...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.052209199